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"It is good practice to deep-clean your brushes at least once a week - more if the brush touches your mouth, eyes, open skin (such as blemishes) or you leave your brushes uncovered where dirt and dust can accumulate," she said. Bartlett, Glamsquad's artistic director, echoed the importance of deep-cleaning your makeup brushes weekly. "Deep-clean your brushes with an antimicrobial shampoo or soap, preferably using a textured silicone mat, once a week." Simone Xavier, founder and chief creative officer of Sigma Beauty, explains. "You should sanitize your brushes with a makeup brush spray after each use," Dr. Expert Tips for Cleaning Your Makeup Brushes Plus, if you're trying not to touch your face as often, you should also make sure you're cleaning your makeup brushes on a regular basis. Giving your makeup brushes a proper cleaning is as necessary as washing your face before bed, yet we tend to forget about doing it regularly. But one area that often gets overlooked is our makeup stash and brushes. These days, it's safe to say that we’ve become hyperaware of germs and the importance of proper cleaning in our daily lives.